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折扣/货期| 货号：27245 | 规格：1 mg | 目录价：￥11256 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
4β-Hydroxywithanolide E
别名:
NSC 212509
产品描述:
A withanolide steroidal lactone with anti-inflammatory and anticancer activities; inhibits LPS-induced NO production in RAW 264.7 cells and TNF-α-induced NF-κB activity in HEK293 cells (IC50s = 0.32 and 0.04 μM, respectively); inhibits LPS-induced increases in iNOS and COX-2 levels and Akt and STAT1 phosphorylation in RAW 264.7 cells at 5 μM; inhibits Wnt signaling in HCT116 and SW480 colorectal cancer cells (IC50s = 1.85 and 2.67 μM, respectively); inhibits the proliferation of HCT116, SW480, HT-29, and LoVo cells (IC50s = 0.24-0.51 μM); halts the cell cycle at the G0/G1 phase in HCT116 and HT-29 cells and induces apoptosis in HCT116 and SW480 cells; reduces tumor growth in an HCT116 mouse xenograft model at 10 mg/kg per day for 14 days
保存温度:
-20
运输温度:
-20
预期分子量:
502.59652
产品形式:
A crystalline solid
纯度:
≥95%
来源:
Plant/Physalis peruviana
CAS号:
54334-04-2
分子式:
C28H38O8
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