官网链接
折扣/货期| 货号：10587-1 mg | 规格：1 mg | 目录价：￥657 |
| 货号：10587-10 mg | 规格：10 mg | 目录价：￥3471 |
| 货号：10587-25 mg | 规格：25 mg | 目录价：￥7062 |
| 货号：10587-5 mg | 规格：5 mg | 目录价：￥2064 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
ABC294640
别名:
Opaganib
产品描述:
An inhibitor of sphingolipid metabolism; originally identified as a selective inhibitor of SPHK2 (IC50 = ~60 µM for the recombinant human enzyme) without activity against SPHK1 up to 100 μM but was later shown to inhibit recombinant human SPHK1 and SPHK2 by 32-34% and 21%, respectively, at 50 µM; reduces SPHK1a protein levels in LNCaP-AI cells via an SPHK1-indirect, proteasomal-dependent mechanism from 5-25 µM; inhibits DES1 (IC50 = 10.2 µM in Jurkat cells); inactive against a panel of 20 lipid-regulated kinases at 50 μM; decreases S1P production in MDA-MB-231 cells but increases S1P and dhS1P levels in Chang, HepG2, and HK-2 cells and HUVECs; inhibits the proliferation of several cancer cell lines (IC50s = 6-48.1 µM); reduces actin filament polymerization in, and migration of, A-498 cells in a scratch assay; reduces tumor growth in a mouse syngeneic model of mammary adenocarcinoma; reduces TNBS-induced colonic inflammation in mouse and rat models of Crohn’s disease
保存温度:
-20
运输温度:
-20
预期分子量:
380.9
产品形式:
A crystalline solid
纯度:
≥98%
CAS号:
915385-81-8
分子式:
C23H25ClN2O
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