ACY-1215-抑制剂-深圳欣博盛生物科技有限公司

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ACY-1215

品牌：Cayman

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说明书

折扣/货期

货号：21531-100 mg	规格：100 mg	目录价：￥3363
货号：21531-25 mg	规格：25 mg	目录价：￥1072
货号：21531-250 mg	规格：250 mg	目录价：￥7290
货号：21531-50 mg	规格：50 mg	目录价：￥1903

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

ACY-1215

别名:

ACY-63|Ricolinostat|Rocilinostat

产品描述:

An inhibitor of HDAC6 (IC50 = 0.0047 µM).{33843} selective for HDAC6 over HDAC1, -2, -3, and -8 (IC50s = 0.058, 0.048, 0.051, and 0.1 µM, respectively), HDAC4, -5, -7, and -9 (IC50s = 7, 5, 1.4 and >10 µM, respectively), SIRT1 and SIRT2 (IC50s = >10 µM for both), and HDAC11 (IC50 = >10 µM); induces accumulation of acetylated α-tubulin in OCI-LY10 cells from 0.5-2.5 µM; induces cytotoxicity in several multiple myeloma cell lines (IC50s = 2-8 µM); decreases tumor volume and increases survival in an OCI-LY10 mouse xenograft model at a 50 mg/kg in combination with bortezomib; decreases liver and kidney cyst area and liver fibrosis in PCK rats in a model of polycystic liver disease

保存温度:

-20

运输温度:

-20

预期分子量:

433.5

产品形式:

A crystalline solid

纯度:

≥98%

CAS号:

1316214-52-4