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折扣/货期| 货号：18-715 | 规格：100 uL | 目录价：￥9477 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
AIF Antibody, KO Validated
别名:
AIF Antibody: CNK, KSR, CNK1, Connector enhancer of kinase suppressor of ras 1, CNK homolog protein 1, Connector enhancer of KSR 1
反应种属:
Human,Mouse,Rat
宿主来源:
Rabbit
实验应用:
WB,IHC,IF,IP
同种型:
IgG
克隆性:
Polyclonal
纯化方式:
Affinity purification
偶联:
Unconjugated
产品浓度:
batch dependent
保存温度:
Store at -20˚C. Avoid freeze / thaw cycles.
运输温度:
Blue Ice
产品形式:
Liquid
存储溶液:
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
产地:
美国
生产商:
Prosci
功能与背景:
This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6 (COXPD6), a severe mitochondrial encephalomyopathy, as well as Cowchock syndrome, also known as X-linked recessive Charcot-Marie-Tooth disease-4 (CMTX-4), a disorder resulting in neuropathy, and axonal and motor-sensory defects with deafness and mental retardation. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 10.
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