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折扣/货期| 货号：AG-CP3-7003-M001 | 规格：1 mg | 目录价：￥540 |
| 货号：AG-CP3-7003-M005 | 规格：5 mg | 目录价：￥1800 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Amastatin . hydrochloride
别名:
[(2S,3R)-3-Amino-2-hydroxy-5-methyl-hexanoyl]-Val-Val-Asp-OH . HCl
产品描述:
Slow, tight binding and competitive aminopeptidase (AP) inhibitor. Inhibits cytosolic leucine aminopeptidase, microsomal aminopeptidase M and bacterial leucine aminopeptidase, human serum aminopeptidase A (AP-A), aminopeptidase N (AP-N), tyrosine aminopeptidase, but not aminopeptidase B (AP-B). Amastatin is without effect on trypsin, papain, chymotrypsin, elastase, pepsin or thermolysin. Inhibits completely the Suc-Ala-Ala-Pro-Leu-pNA amidolytic enzyme. Slightly inhibits the formation of angiotensin III (Ang III) from Angiotensin II through AP-A, but significantly increases the potency of angiotensin III and [des-Asp1]-angiotensin I. Moderate inhibitor of mitochondrial intermediate peptidase (MIP). Weak inhibitor of simian immunodeficiency virus protease (SIV-PR). ANPEP (aminopeptidase N) is a host receptor targeted by porcine epidemic diarrhoea virus, human coronavirus 229E, feline coronavirus, canine coronavirus, transmissible gastroenteritis virus and infectious bronchitis virus. These viruses all belong to coronaviridae. ANPEP is therefore investigated as a potential target for SARS-CoV-2 infections.
宿主来源:
Synthetic.
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
474.6 . 36.5
产品形式:
solid
有效期:
Stable for at least 2 years after receipt when stored at -20°C.
产地:
瑞士
纯度:
>98% (HPLC)
CAS号:
100938-10-1
分子式:
C21H38N4O8 . HCl
溶解度:
Soluble in DMF, ethanol, DMSO or aqueous solvents (PBS).
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