anti-Akt1 (human), Rabbit Monoclonal (RM252)-单抗-深圳欣博盛生物科技有限公司

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anti-Akt1 (human), Rabbit Monoclonal (RM252)

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：REV-31-1132-00-R100

规格：100 ul

目录价：￥5726

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

anti-Akt1 (human), Rabbit Monoclonal (RM252)

别名:

PKB; AKT1; PKB alpha; EC=2.7.11.1; RAC-PK-alpha; Protein Kinase B; Proto-Oncogene c-Akt; Protein Kinase B alpha; PKBG; AKT3; STK-2; PKB gamma; RAC-PK-gamma; Protein Kinase Akt-3; Protein Kinase B gamma; AKT2; PKB beta; RAC-PK-beta; Protein

产品描述:

Akt, also referred to as PKB or Rac, plays a critical role in controlling survival and apoptosis. This protein kinase is activated at 2 phosphorylation sites Thr308 and Ser473. Akt promotes cell survival by inhibiting apoptosis through phosphorylation and inactivation of several targets, including Bad, forkhead transcription factors, c-Raf and caspase-9. In addition to its role in survival and glycogen synthesis, Akt is involved in cell cycle regulation. Akt also plays a critical role in cell growth by directly phosphorylating mTOR in a rapamycin-sensitive complex containing raptor. Mutation of the glutamic acid at residue 17 to lysine (E17K) of Akt was initially identified in human breast, colorectal and ovarian cancers. This conserved glutamic acid residue is located at the lipid-binding pocket of the Akt plextrin homology domain. The E17K mutation increases the affinity between Akt and phospholipids at the plasma membrane, leading to increased Akt recruitment, super-activation of the Akt pathway, cellular transformation and tumor formation. Additional studies detect the presence of the Akt (E17K) mutation in multiple cancers, including lung cancer, prostate cancer, endometrial carcinoma and several melanomas.

宿主来源:

Rabbit

实验应用:

IHC, WB

靶标/特异性:

This antibody reacts to human Akt1. This antibody may also react to bovine, mouse or rat Akt1, as predicted by immunogen homology.

同种型:

Rabbit IgG

免疫原:

A synthetic peptide corresponding to the C-terminus of human Akt1.

克隆号:

RM252