anti-BTLA (human), mAb (6F4)-单抗-深圳欣博盛生物科技有限公司

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anti-BTLA (human), mAb (6F4)

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：AG-20B-0049-C100

规格：100 ug

目录价：￥4320

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

anti-BTLA (human), mAb (6F4)

别名:

B and T Lymphocyte Associated; Lymphotoxin-beta Receptor; Tumor Necrosis Factor Receptor 2 Related Protein; Tumor Necrosis Factor C Receptor; Tumor Necrosis Factor Receptor Superfamily Member 3; TNFRSF3

产品描述:

B and T lymphocyte associated (BTLA) is an Ig domain superfamily protein with cytoplasmic immunoreceptor tyrosine-based inhibitory motifs. The herpes virus entry mediator (HVEM), a member of the TNF receptor (TNFR) superfamily, can act as a molecular switch that modulates T cell activation by propagating positive signals from the TNF-related ligand LIGHT (TNFR superfamily 14), or inhibitory signals through the Ig superfamily member BTLA. The binding site on HVEM for BTLA is conserved in the orphan TNF receptor UL144, present in human CMV. UL144 binds BTLA, but not LIGHT, and inhibits T cell proliferation, selectively mimicking the inhibitory function of HVEM. BTLA also interacts with HVEM in cis, forming a heterodimeric complex in naive T cells that inhibits HVEM-dependent signaling. The cis-interaction between HVEM and BTLA is the predominant form expressed on the surface of naive human and mouse T cells and may be important to limit trans-signaling by LIGHT, BTLA, and CD160 that are expressed in adjacent activated cells.

宿主来源:

Purified from concentrated hybridoma tissue culture supernatant.

实验应用:

ELISA, FACS

靶标/特异性:

Recognizes human BTLA.

同种型:

Rat IgG1

免疫原:

Ectodomain of human BTLA fused to human IgG Fc.

克隆号:

6F4