anti-Caspase-2, mAb (10C6)-单抗-深圳欣博盛生物科技有限公司

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anti-Caspase-2, mAb (10C6)

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：AG-20T-0135-C100

规格：100 ug

目录价：￥3840

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

anti-Caspase-2, mAb (10C6)

别名:

CASP-2; Protease ICH-1; Neural Precursor Cell Expressed Developmentally Down-regulated Protein 2; NEDD-2

产品描述:

Caspase-2 is a Class I caspase with a long prodomain necessary for nuclear localization. Upon activation of the apoptotic pathway, the procaspase is cleaved into smaller fragments. Caspase-2 is the nuclear apoptotic respondent to cellular genotoxic stress or mitotic catastrophe and is involved in the activation cascade of caspases responsible for apoptosis execution. Activation occurs upon recruitment to a complex containing a p53-induced death domain protein, PIDD. This suggests caspase-2 can be a nuclear initiator caspase with a requirement for caspase-9 and caspase-3 activation in downstream apoptotic events. In apoptotic pathways resulting from UV-induced DNA damage, processing of caspase-2 occurs downstream of mitochondrial dysfunction and of caspase-9 and caspase-3 activation, extending a possible role for caspase-2 as a parallel effector caspase.

实验应用:

ELISA, FACS, ICC, IHC

靶标/特异性:

Recognizes an epitope in the p19 subunit of human, mouse, rat, monkey and dog caspase-2.

同种型:

Rat IgG2akappa

免疫原:

Recombinant human caspase-2 (p19 subunit).

克隆号:

10C6

产品浓度:

1mg/ml