anti-Caspase-4/11 (p20), mAb (Flamy-1) (25 ug)-单抗-深圳欣博盛生物科技有限公司

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anti-Caspase-4/11 (p20), mAb (Flamy-1) (25 ug)

品牌：Adipogen

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说明书

折扣/货期

货号：AG-20B-0060-C100	规格：100 ug	目录价：￥4080
货号：AG-20B-0060-TRIAL	规格：25 ug	目录价：￥1740

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

anti-Caspase-4/11 (p20), mAb (Flamy-1) (25 ug)

别名:

Caspase-11 (mouse); Caspase-4 (human); ICE(rel)-II (human); Protease ICH-2 (human); Protease TX (human); Protease ICH-3 (mouse)

产品描述:

Inflammatory caspases (also known as group I caspases) are encoded by three main genes in humans, caspase-1, caspase-4 and caspase-5 and three main genes in mouse, caspase-1, caspase-11 and caspase-12. Caspase-11 is the murine orthologue of human caspase-4 and -5. Murine caspase-11 is a poorly characterized member of the caspase-1 subfamily. Caspase-11-deficient embryonic fibroblasts are resistant to apoptosis induced by ectopic expression of caspase-1, suggesting that caspase-11 is an upstream activator of caspase-1. Unlike caspase-1, the expression of caspase-11 is LPS-inducible and it is reasonable to postulate that other members of the family are regulated at the transcriptional or translational level by extracellular stimuli. Recently caspase-11 has been shown to be required for activation of the Nlrp3 inflammasome upon E. coli, V. cholerae and C. rodentium infection. The upstream activators of caspase-11 are TLR4 and TRIF, that modulate enteropathogen-induced inflammasome activation by promoting caspase-11 expression and activation. Formation of ASC foci (specks), a measure of NLRP3/ASC complex formation, requires caspase-11 but not caspase-1 indicating that caspase-11 acts upstream of the NLRP3/ASC complex.

宿主来源:

Purified from concentrated hybridoma tissue culture supernatant.

实验应用:

IP, WB

靶标/特异性:

Recognizes endogenous full-length protein and activated (p20) fragment of mouse and human caspase-4/11. Does not detect human Caspase-5.

同种型:

Mouse IgG2bkappa

免疫原:

Recombinant mouse Caspase-11 (aa 81-373).

克隆号:

Flamy-1