anti-Caspase-8 (mouse), mAb (1G12)-单抗-深圳欣博盛生物科技有限公司

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anti-Caspase-8 (mouse), mAb (1G12)

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：AG-20T-0137-C100

规格：100 ug

目录价：￥3480

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

anti-Caspase-8 (mouse), mAb (1G12)

别名:

Apoptotic Cysteine Protease; Apoptotic Protease Mch-5; CAP4; FADD-homologous ICE/ced-3-like Protease

产品描述:

Procaspase-8 belongs to the family of caspases. Binding of FasL to Fas leads to formation of a receptor complex at the cellular membrane, which was named DISC. The DISC consists of oligomerized receptors, the DD-containing adaptor molecule FADD, procaspase-8, procaspase-10 and c-FLIP. The DISC structure provides a platform for the oligomerization of procaspase-8 that allows two procaspase-8 homodimers to be in the close proximity leading to the initial activation of procaspase-8. At the first cleavage step, the N-terminal p43/p41 and the C-terminal p30 cleavage products are generated. Importantly, these cleavage products already possess catalytic activity. At the second cleavage step, p43/p41 and p30 are processed to p10 and p20, respectively, which leads to the generation of the active caspase-8 heterotetramer (p20/p10)2.

实验应用:

ELISA, FACS, IHC, WB

靶标/特异性:

Recognizes the p20 subunit of mouse caspase-8. Detects bands of ~55kDa (full-length caspase-8) and ~18kDa (apoptosis-induced cleavage fragment) by Western blot. Does not cross-react with human caspase-8.

同种型:

Rat IgG1kappa

免疫原:

Recombinant mouse caspase-8 (p20 subunit).

克隆号:

1G12

产品浓度:

1mg/ml

保存温度:

+4°C

运输温度:

产品形式: