anti-CD20 (human), Rabbit Monoclonal (RM272)-单抗-深圳欣博盛生物科技有限公司

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anti-CD20 (human), Rabbit Monoclonal (RM272)

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：REV-31-1153-00-R100

规格：100 ul

目录价：￥5964

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

anti-CD20 (human), Rabbit Monoclonal (RM272)

别名:

B-lymphocyte Surface Antigen B1; Bp35 Leukocyte Surface Antigen Leu-16; Membrane-spanning 4-domains Subfamily A Member 1

产品描述:

CD20 is a non-glycosylated surface phosphoprotein that has a molecular weight range of 33-37 kDa depending on the degree of phosphorylation. CD20 is expressed on mature and most malignant B cells, in a subpopulation of T lymphocytes and follicular dendritic cells. CD20 expression on B cells is synchronous with the expression of surface IgM and it regulates transmembrane calcium conductance, cell cycle progression and B cell proliferation. CD20 is also associated with lipid rafts, but the intensity of this association depends on extracellular triggering, employing CD20 conformational change, and/or BCR (B cell antigen receptor) aggregation. After the receptor ligation, BCR and CD20 colocalize and then rapidly dissociate before BCR endocytosis, whereas CD20 remains at the cell surface. CD20 serves as a useful target for antibody-mediated therapeutic depletion of B cells, as it is expressed at high levels on most B-cell malignancies, but does not become internalized or shed from the plasma membrane following monoclonal antibody treatment. Diseases associated with CD20 dysfunction include Ms4a1-related common variable immune deficiency, B cell non-Hodgkin's lymphoma or chronic lymphocytic leukaemia (CLL).

宿主来源:

Rabbit

实验应用:

IHC, WB

靶标/特异性:

This antibody reacts to the cytoplasmic domain of human CD20.

同种型:

Rabbit IgG

免疫原:

A peptide corresponding to the C-terminus of human CD20.

克隆号:

RM272