anti-CD30 (human), mAb (rec.) (SH313-B5)-单抗-深圳欣博盛生物科技有限公司

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anti-CD30 (human), mAb (rec.) (SH313-B5)

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：AG-27B-6314-C050

规格：50 ug

目录价：￥3492

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

anti-CD30 (human), mAb (rec.) (SH313-B5)

别名:

CD30L Receptor; Ki-1 Antigen; Tumor Necrosis Factor Receptor Superfamily Member 8; TNFRSF8

产品描述:

CD30 (Ki-1; TNF Receptor Superfamily Member 8) is a type I transmembrane glycoprotein of the TNF receptor superfamily. CD30 was originally identified as a cell surface antigen of Hodgkins and Reed-Sternberg cells using monoclonal antibody Ki-1. The ligand for CD30 is CD30L (CD153). The binding of CD30 to CD30L mediates pleiotropic effects including cell proliferation, activation, differentiation and apoptotic cell death. CD30 has a critical role in the pathophysiology of Hodgkin's disease and other CD30+ lymphomas. CD30 acts as a costimulatory molecule in thymic negative selection. In addition to its expression on Hodgkin's and Reed-Sternberg cells, CD30 is also found in some non-Hodgkin's lymphomas (including Burkitt's lymphomas), virus-infected T and B cells, and on normal T and B cells after activation. In T cells, CD30 expression is present on a subset of T cells that produce Th2-type cytokines and on CD4+/CD8+ thymocytes that co-express CD45RO and the IL4 receptor. Soluble form of CD30 (sCD30) serves as a marker reflecting Th2 immune response. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. CD30 is a positive regulator of apoptosis, and has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity.

宿主来源:

Protein A purified from HEK293 cell culture supernatant.

实验应用:

ELISA, FACS, FUNC, ICC, WB

靶标/特异性:

Recognizes human CD30.

同种型:

Human IgG1

免疫原:

Recombinant human CD30 containing a C-terminal human Fc-tag.

克隆号:

SH313-B5