anti-HMGB1, mAb (rec.) (Giby-1-4) (25 ug)-单抗-深圳欣博盛生物科技有限公司

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anti-HMGB1, mAb (rec.) (Giby-1-4) (25 ug)

品牌：Adipogen

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说明书

折扣/货期

货号：AG-27B-0002-C100	规格：100 ug	目录价：￥3480
货号：AG-27B-0002-TRIAL	规格：25 ug	目录价：￥1740

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

anti-HMGB1, mAb (rec.) (Giby-1-4) (25 ug)

别名:

High Mobility Group Protein B1

产品描述:

HMGB1 was originally discovered as an essential DNA-binding protein for regulating p53, NF-kappaB and other important proteins. It is secreted from activated dentric cells, macrophage and nectrotic cells, and acts as a ligand for RAGE, TLR-2 and TLR-4 expressed on surrounding cells. As a result, HMGB1 activates Rac, CDC42 and NF-kappaB inducing localized innate immunity of damaged tissue, tissue regeneration by recruitment of stem cells and hemostasis by induction of tissue factor expression. HMGB1 is also a causative agent of various diseases as it causes localized inflammation such as arteriosclerosis, chronic rheumatoid arthritis and nephritis. Anti-HMGB1, mAb (recombinant) (Giby-1-4) is an antibody developed by antibody phage display technology using a human naive antibody gene library. These libraries consist of scFv (single chain fragment variable) composed of VH (variable domain of the human immunoglobulin heavy chain) and VL (variable domain of the human immunoglobulin light chain) connected by a polypeptide linker. The antibody fragments are displayed on the surface of filamentous bacteriophage (M13). This scFv was selected by affinity selection on antigen in a process termed panning. Multiple rounds of panning are performed to enrich for antigen-specific scFv-phage. Monoclonal antibodies are subsequently identified by screening after each round of selection. The selected monoclonal scFv is cloned into an appropriate vector containing a Fc portion of interest and then produced in mammalian cells to generate an IgG like scFv-Fc fusion protein.

宿主来源:

Produced without the use of animals. Purified from HEK 293 cell culture supernatant.

实验应用:

ELISA, WB

靶标/特异性:

Recognizes human, mouse and rat HMGB1.

同种型:

Human IgG2lambda

免疫原:

Human recombinant HMGB1.

克隆号:

Giby-1-4