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折扣/货期| 货号：AG-27B-7001PF-C100 | 规格：100 ug | 目录价：￥4560 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
anti-IL-11, mAb (rec.) (blocking) (X203) (preservative free)
别名:
Interleukin-11; Adipogenesis Inhibitory Factor; AGIF
产品描述:
Interleukin-11 (IL-11) is a 19 kDa monomeric protein. IL-11 forms a hexameric signaling complex, which consists of the cytokine, the cognate receptor (IL-11Ralpha) and the common signaling receptor (GP130) in a 2:2:2 stoichiometry. Interleukin-11 (IL-11) belongs to the IL-6 family of cytokines, which includes IL-6, leukemia inhibitory factor, Oncostatin M, ciliary neurotrophic factor, cardiotrophin-1, cardiotrophin-like cytokine, neuropoietin, IL-27 and IL-31. Interleukin-11 (IL-11) has diverse biological activities: i) it stimulates the proliferation and differentiation of hematopoietic stem cells and progenitor cells, enhances the production of megakaryocytes, leading to increased platelet production (thrombopoiesis); ii) IL-11 activates fibroblasts and exhibits either a pro-inflammatory or pro-fibrotic phenotype. Recently, IL-11 has been shown to be a key factor in 'inflammaging' (chronic inflammation), one of the hallmarks of aging leading to age-related illnesses, including cardiometabolic, neurodegenerative, musculoskeletal dysfunction and cancer. Inhibition of IL-11 has been shown to increase lifespan and health span in mice. IL-11 influences aging by inducing IL-33 in fibroblasts and NLRP3 in macrophages. The clone X203 effectively inhibited IL-11-mediated activation of downstream STAT3 phosphorylation and blocks IL-11-dependent gene expression in vitro and in vivo. It neutralizes both human and murine IL-11, demonstrated blockade of IL-11-STAT3 signaling axis, reduced pro-fibrotic transcriptional responses in multiple models, and has been used in preclinical models of renal fibrosis, aging-associated inflammation, and oncogenesis. So, inhibition of IL-11 by X203 is a potential new approach to reduce inflammation during aging and increase human healthspan and lifespan.
宿主来源:
CHO cells
实验应用:
FUNC (Blocking), WB
靶标/特异性:
Recognizes and binds to human and mouse IL-11.
同种型:
Mouse IgG2akappa
免疫原:
Recombinant human interleukin-11 (aa22-199).
克隆号:
X203
偶联:
Preservative Free
产品浓度:
1mg/ml
保存温度:
+4°C
运输温度:
BI
产品形式:
liquid
存储溶液:
Liquid. In PBS.
产地:
瑞士
纯度:
>95% (SDS-PAGE)
内毒素水平:
<0.01EU/µg
上一个:anti-APRIL (mouse), mAb (rec.) (blocking) (Apry-1-1) (Fc LAEA-PG) (25 ug)
下一个:Anti-GFP antibody, mouse monoclonal(S2H12)
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