anti-IL-36gamma (human), mAb (Jussy-1) (25 ug)-单抗-深圳欣博盛生物科技有限公司

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anti-IL-36gamma (human), mAb (Jussy-1) (25 ug)

品牌：Adipogen

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说明书

折扣/货期

货号：AG-20B-0072-C100	规格：100 ug	目录价：￥3600
货号：AG-20B-0072-TRIAL	规格：25 ug	目录价：￥1740

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

anti-IL-36gamma (human), mAb (Jussy-1) (25 ug)

别名:

Interleukin-36gamma; Interleukin-1 Family Member 9; IL-1F9

产品描述:

IL-36alpha (IL-1F6), IL-36beta (IL-1F8) and IL-36gamma (IL-1F9) bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1 and are inhibited by IL-36Ra. The expression of IL-36 cytokines has been shown to occur at different sites including the lung and skin and can be derived from diverse cell types including keratinocytes, bronchial epithelium as well as macrophages, monocytes and different T cell subsets. IL-36 family members induce the production of proinflammatory cytokines, including IL-12, IL-1beta, IL-6, TNF-alpha and IL-23 in BMDC and CD4 T cells, thus promoting neutrophil influx, dendritic cell (DC) activation, polarization of T helper type 1 (Th1) and IL-17-producing T cells (alphabeta T cells and gammadelta T cells) and keratinocyte proliferation. These cytokines may represent potential targets for immune-mediated inflammatory conditions or, alternatively, could be used as adjuvants in vaccination. IL-36gamma is also induced in the lung in various models of asthma and can be produced by bronchial epithelial cells in response to viral infection, smoke or inflammatory cytokines.

宿主来源:

Purified from concentrated hybridoma tissue culture supernatant.

实验应用:

ELISA, WB

靶标/特异性:

Recognizes human IL-36gamma.

同种型:

Mouse IgG1kappa

免疫原:

Recombinant human IL-36gamma.

克隆号:

Jussy-1