anti-Ki-67 (human), Rabbit Monoclonal (RM521)-单抗-深圳欣博盛生物科技有限公司

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anti-Ki-67 (human), Rabbit Monoclonal (RM521)

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：REV-31-1413-00-R100

规格：100 ul

目录价：￥5726

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

anti-Ki-67 (human), Rabbit Monoclonal (RM521)

别名:

Proliferation Marker Protein Ki-67

产品描述:

Ki-67 is a nuclear protein that is expressed during various stages in the cell cycle, particularly during the late G1, S, G2, and M phases. The protein has a forkhead-associated domain (FHA) through which it associates with euchromatin at the peri chromosomal layer, the centromeric heterochromatin and the nucleolus. Ki-67 is shown to have a cell cycle-dependent topographical distribution with perinucleolar expression at G1, expression in the nuclear matrix at G2 and expression on the chromosomes during M phase. Ki-67 is commonly used as a proliferation marker because it is not detected in G0 cells, but increases steadily from G1 through mitosis. Ki-67 antibodies are useful in establishing the cell growing fraction in neoplasms. In neoplastic tissues, the prognostic value is comparable to the tritiated thymidine-labelling index. The correlation between low Ki-67 index and histologically low-grade tumors is strong. Ki-67 is routinely used as a neuronal marker of cell cycling and proliferation. In breast cancer, Ki67 identifies a high proliferative subset of patients with ER-positive breast cancer who derive greater benefit from adjuvant chemotherapy.

宿主来源:

Rabbit

实验应用:

IHC, WB

靶标/特异性:

This antibody reacts to human Ki-67.

同种型:

Rabbit IgG

免疫原:

A peptide corresponding to the internal region of human Ki-67.

克隆号:

RM521