anti-Lipoma Preferred Partner, pAb (IG-817)-多抗-深圳欣博盛生物科技有限公司

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anti-Lipoma Preferred Partner, pAb (IG-817)

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：AG-25T-0106-C050

规格：50 ug

目录价：￥6360

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

anti-Lipoma Preferred Partner, pAb (IG-817)

别名:

LPP; LIM Domain-containing Preferred Translocation Partner in Lipoma

产品描述:

Lipoma preferred partner (LPP) is encoded by the preferred fusion partner gene of the high mobility group protein HMGI-C. LPP is frequently affected by chromosomal translocations in a major group of soft tissue lipomas, as well as in a parosteal lipoma and in pulmonary chondroid hamartomas. The resulting fusion proteins comprise three DNA binding domains of HMGI-C fused to two or three C-terminal LIM domains of LPP and a reciprocal product, respectively. Expression of a HMGI-C/LPP fusion protein causes malignant transformation of fibroblasts. Similar to its relatives zyxin and TRIP (thyroid receptor interacting protein 6) / ZRP-1 (zyxin-related protein 1), LPP consists of a N-terminal proline-rich domain followed by three C-terminal LIM domains (double zinc finger structures that are involved in protein-protein interactions). Like the cytoskeletal protein zyxin, LPP localizes to focal adhesions and cell-cell adherens junctions. LPP harbors a nuclear export signal and displays transcriptional activation capacity.

宿主来源:

Rabbit

实验应用:

ICC, IP, WB

靶标/特异性:

Recognizes human, rat and pig LPP.

免疫原:

Recombinant human lipoma preferred partner (LPP) (aa 1-109).

产品浓度:

500µg/ml

保存温度:

+4°C