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折扣/货期| 货号：REV-31-1362-00-R100 | 规格：100 ul | 目录价：￥5726 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
anti-p44 MAPK (Erk1), Rabbit Monoclonal (RM470)
别名:
Mitogen-activated protein kinase 3; MAPK3; MAP kinase isoform p44 (p44-MAPK); p44-Erk1
产品描述:
Extracellular signal-regulated kinases 1 and 2 (also known as ERK1/2, p44/42, or MAPK3/1) belong to a family of conserved serine/threonine protein kinases known as mitogen-activated protein kinases (MAPKs) that are involved in many cellular programs such as proliferation, differentiation, motility and survival. The ERK1/2 signaling pathway can be activated in response to a diverse range of extracellular stimuli including mitogens, growth factors and cytokines. The primary activators of ERK1/2 are MEK1 and MEK2 which activate p44 and p42 through phosphorylation of activation loop residues Thr202/Tyr204 and Thr185/Tyr187 in ERK1 and ERK2, respectively. Several downstream targets of ERK1/2 have been identified, including p90RSK and the transcription factor Elk-1. ERK1/2 are negatively regulated by MAPK phosphatases as well as by chemical inhibitors of MEK. The ERK pathway is disrupted in many types of cancer and thus is an important target for diagnosis and treatment.
宿主来源:
Rabbit
实验应用:
IHC, WB
靶标/特异性:
RM470 reacts to human Erk1 (p44-MAPK).
同种型:
Rabbit IgG
免疫原:
A peptide corresponding to the C-terminus of human Erk1 (p44-MAPK).
克隆号:
RM470
保存温度:
+4°C
运输温度:
BI
产品形式:
liquid
存储溶液:
Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide.
产地:
瑞士
纯度:
Protein A purified.
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