anti-PD-1 (mouse), mAb (blocking) (1H10) (25 ug)-单抗-深圳欣博盛生物科技有限公司

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anti-PD-1 (mouse), mAb (blocking) (1H10) (25 ug)

品牌：Adipogen

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说明书

折扣/货期

货号：AG-20B-0075-C100	规格：100 ug	目录价：￥2280
货号：AG-20B-0075-TRIAL	规格：25 ug	目录价：￥1320

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

anti-PD-1 (mouse), mAb (blocking) (1H10) (25 ug)

别名:

CD279; Programmed Cell Death Protein 1

产品描述:

CD279 (Programmed Cell Death Protein 1; PD-1) is a type I transmembrane protein belonging to the CD28/CTLA-4 family of immunoreceptors that mediate signals for regulating immune responses. Members of the CD28/CTLA-4 family have been shown to either promote T cell activation (CD28 and ICOS) or downregulate T cell activation (CTLA-4 and PD-1). CD279 is expressed on activated T cells, B cells, myeloid cells and on a subset of thymocytes. In vitro, ligation of CD279 inhibits TCR-mediated T cell proliferation and production of IL-1, IL-4, IL-10 and IFN-gamma. In addition, CD279 ligation also inhibits BCR mediated signaling. CD279 deficient mice have a defect in peripheral tolerance and spontaneously develop autoimmune diseases.

宿主来源:

Purified from concentrated hybridoma tissue culture supernatant.

实验应用:

FACS, FUNC (Blocking)

靶标/特异性:

Recognizes mouse PD-1 (CD279). Does not cross-react with human PD-1d.

同种型:

Rat IgG2akappa

免疫原:

Mouse PD-1 transfected cell line.

克隆号:

1H10