anti-Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204), Rabbit Monoclonal (RM451)-单抗-深圳欣博盛生物科技有限公司

首页产品中心单抗

anti-Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204), Rabbit Monoclonal (RM451)

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：REV-31-1343-00-R100

规格：100 ul

目录价：￥5726

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

anti-Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204), Rabbit Monoclonal (RM451)

别名:

Mitogen-activated Protein Kinase p44/42

产品描述:

Extracellular signal-regulated kinases 1 and 2 (also known as ERK1/2, p44/42, or MAPK3/1) belong to a family of conserved serine/threonine protein kinases known as mitogen-activated protein kinases (MAPKs) that are involved in many cellular programs such as proliferation, differentiation, motility and survival. The ERK1/2 signaling pathway can be activated in response to a diverse range of extracellular stimuli including mitogens, growth factors and cytokines. The primary activators of ERK1/2 are MEK1 and MEK2 which activate p44 and p42 through phosphorylation of activation loop residues Thr202/Tyr204 and Thr185/Tyr187 in ERK1 and ERK2, respectively. Several downstream targets of ERK1/2 have been identified, including p90RSK and the transcription factor Elk-1. ERK1/2 are negatively regulated by MAPK phosphatases as well as by chemical inhibitors of MEK. The ERK pathway is disrupted in many types of cancer and thus is an important target for diagnosis and treatment.

宿主来源:

Rabbit

实验应用:

IHC, WB

靶标/特异性:

This antibody reacts to human p44/42 MAPK (Erk1/2) only when phosphorylated at Thr202 and Tyr204. There is no cross-reactivity to Erk1/2 that is not phosphorylated. This antibody may also react to mouse or rat Phospho- Erk1/2 (Thr203/Tyr205) as predicted by immunogen homology.

同种型:

Rabbit IgG

免疫原:

A phospho-peptide corresponding to human Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204).

克隆号:

RM451

产品浓度:

N/A

保存温度:

+4°C

运输温度:

产品形式: