anti-Phospho-Tau (Ser396), Rabbit Monoclonal (RM461)-单抗-深圳欣博盛生物科技有限公司

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anti-Phospho-Tau (Ser396), Rabbit Monoclonal (RM461)

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：REV-31-1353-00-R100

规格：100 ul

目录价：￥5726

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

anti-Phospho-Tau (Ser396), Rabbit Monoclonal (RM461)

产品描述:

Tau is a neuronal microtubule-associated protein found predominantly on axons. The function of Tau is to promote tubulin polymerization and stabilize microtubules. The C-terminus binds axonal microtubules while the N- terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton while the longer isoforms may preferentially play a role in its stabilization. In its hyper-phosphorylated form, Tau is the major component of paired helical filaments (PHF), the building block of neurofibrillary lesions in Alzheimer's diseases (AD) brain. Hyper-phosphorylation impairs the microtubule binding function of Tau, resulting in the destabilization of microtubules in AD brains, ultimately leading to the degeneration of the affected neurons. Numerous serine/threonine kinases phosphorylate Tau, including GSK-3beta, protein kinase A (PKA), cyclin-dependent kinase 5 (cdk5) and casein kinase II. Hyper-phosphorylated Tau is found in neurofibrillary lesions in a range and other central nervous system disorders such as Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.

宿主来源:

Rabbit

实验应用:

IHC, WB

靶标/特异性:

This antibody reacts to Tau only when phosphorylated at Ser396. There is no cross-reactivity to Tau that is not phosphorylated. This antibody reacts to human, mouse or rat Phospho-Tau (Ser396).

同种型:

Rabbit IgG

免疫原:

A phospho-peptide corresponding to human Tau (Ser396).

克隆号:

RM461

产品浓度:

N/A

保存温度:

+4°C

运输温度:

产品形式: