anti-Poly(ADP-ribose) [PAR], mAb (10H)-单抗-深圳欣博盛生物科技有限公司

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anti-Poly(ADP-ribose) [PAR], mAb (10H)

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：AG-20T-0001-C050	规格：50 ug	目录价：￥2640
货号：AG-20T-0001-C100	规格：100 ug	目录价：￥4080
货号：AG-20T-0001-M001	规格：1 mg	目录价：￥11880

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

anti-Poly(ADP-ribose) [PAR], mAb (10H)

产品描述:

Processes such as transcription, repair and replication that require efficient DNA recognition are dependent on modulation of chromatin structure. Chromatin relaxation is a critical event that occurs during DNA repair and is associated with the negatively charged polymer of adenosine 5'-diphosphate (ADP)-ribose (PAR). PAR is synthesized from nicotinamide adenine dinucleotide (NAD+) by the poly(ADP-ribose) polymerase protein family (PARPs), of which PARP-1 (and to a lesser extent PARP-2) respond to DNA-strand breaks. PARP-1 is selectively activated by DNA strand breaks to catalyze the addition of long branched chains of PAR to a variety of nuclear proteins, most notably PARP itself. The amount of PAR formed in living cells with DNA damage is commensurate with the extent of the damage. Under DNA damage conditions, PAR undergoes a rapid turnover, with a half-life in the range of minutes, as PAR is rapidly hydrolyzed and converted to free ADP-ribose by the enzyme poly(ADP-ribose)glycohydrolase (PARG). PAR regulates not only cell survival and cell-death programmes, but also an increasing number of other biological functions with which novel members of the PARP family have been associated. These include transcriptional regulation, cell division, intracellular trafficking, inflammation and energy metabolism.

宿主来源:

Purified from concentrated hybridoma tissue culture supernatant.

实验应用:

FACS, ICC, IHC, WB

靶标/特异性:

Recognizes poly(ADP-ribose) synthesized by a broad range of PARPs (poly(ADP-ribose) polymerases), including human, mouse, rat or Drosophila PARP enzymes.

同种型:

Mouse IgG3kappa

免疫原:

Purified poly(ADP-ribose).

克隆号:

10H

产品浓度:

1 mg/ml

保存温度:

+4°C

运输温度:

产品形式: