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折扣/货期| 货号：REV-31-1403-00-R100 | 规格：100 ul | 目录价：￥5558 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
anti-PTEN (human), Rabbit Monoclonal (RM511)
别名:
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and Dual-specificity Protein Phosphatase; Mutated in Multiple Advanced Cancers 1; Phosphatase and Tensin Homolog
产品描述:
PTEN (phosphatase and tensin homologue deleted on chromosome ten) is a tumor suppressor implicated in a wide variety of human cancers. PTEN encodes a 403 amino acid polypeptide and contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. PTEN preferentially dephosphorylates phosphoinositide substrates. PTEN negatively regulates intracellular levels of phosphatidylinositol-3, 4, 5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating PI3K/Akt signaling pathway. PTEN possesses a carboxy-terminal, noncatalytic regulatory domain with three phosphorylation sites (Ser380, Thr382, and Thr383) that regulate PTEN stability and may affect its biological activity. PTEN regulates p53 protein levels and activity and is involved in G protein-coupled signaling during chemotaxis. PTEN plays a role as a key modulator in neurogenesis, including correct neuron positioning, dendritic development and synapse formation and it may be also a negative regulator of insulin signaling and glucose metabolism in adipose tissue. The nuclear monoubiquitinated form possesses greater apoptotic potential, whereas the cytoplasmic nonubiquitinated form of PTEN induces less tumor suppressive ability.
宿主来源:
Rabbit
实验应用:
IHC
靶标/特异性:
This antibody reacts to human PTEN.
同种型:
Rabbit IgG
免疫原:
A peptide corresponding to residues at the C-terminus of human PTEN.
克隆号:
RM511
保存温度:
+4°C
运输温度:
BI
产品形式:
liquid
存储溶液:
Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide.
有效期:
Stable for at least 1 year after receipt when stored at -20°C.
产地:
瑞士
纯度:
Protein A purified.
促销活动
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