anti-Rab1-GTP, mAb (rec.) (ROF7) (25 ug)-单抗-深圳欣博盛生物科技有限公司

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anti-Rab1-GTP, mAb (rec.) (ROF7) (25 ug)

品牌：Adipogen

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说明书

折扣/货期

货号：AG-27B-0006-C100	规格：100 ug	目录价：￥3900
货号：AG-27B-0006-TRIAL	规格：25 ug	目录价：￥1740

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

anti-Rab1-GTP, mAb (rec.) (ROF7) (25 ug)

别名:

Ras-related Protein Rab-1

产品描述:

Rab1 (Ypt1 in yeast) is a small GTPase that plays a well-established role in mediating ER-to-Golgi protein transport in both yeast and mammalian cells. Rab1 recruits effector proteins to budding COPII vesicles at the ER, forming cis-SNARE complexes that promote targeting to and fusion of these vesicles with the cis-Golgi. Rab1 is also involved in COPI vesicle formation and other distinct transport pathways, including ER-to-Golgi intermediate compartment (ERGIC)-to-cell periphery trafficking. Recently Rab1 has been shown to function in antimicrobial autophagy (autophagosome formation), as well as other forms of autophagy in mammalian cells in a way independent of ER-to-Golgi trafficking. anti-Rab1-GTP, monoclonal antibody (recombinant) (ROF7) is an antibody developed by antibody phage display technology using a human naive antibody gene library. These libraries consist of scFv (single chain fragment variable) composed of VH (variable domain of the human immunoglobulin heavy chain) and VL (variable domain of the human immunoglobulin light chain) connected by a polypeptide linker. The antibody fragments are displayed on the surface of filamentous bacteriophage (M13). This scFv was selected by affinity selection on antigen in a process termed panning. Multiple rounds of panning are performed to enrich for antigen-specific scFv-phage. Monoclonal antibodies are subsequently identified by screening after each round of selection. The selected monoclonal scFv is cloned into an appropriate vector containing a Fc portion of interest and then produced in mammalian cells to generate an IgG like scFv-Fc fusion protein.

宿主来源:

Produced without the use of animals. Purified from HEK 293 cell culture supernatant.

实验应用:

ICC, IP

靶标/特异性:

Recognizes human, mouse, rat and dog Rab1a-GTP and Rab1b-GTP.

同种型:

Human IgG2lambda

免疫原:

Full length canine Rab1.

克隆号:

ROF7