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折扣/货期| 货号：REV-31-1314-00-R100 | 规格：100 ul | 目录价：￥5726 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
anti-SOX2 (human), Rabbit Monoclonal (RM427)
别名:
SRY-related HMG-box Gene 2; SRY (Sex Determining Region Y)-Box 2; MCOPS3; ANOP3
产品描述:
SOX2 is the most studied member of SRY-related box transcription factor family. It binds to target genes through its highly conserved HMG box domain. Inactivation of the SOX2 gene causes lethality during embryonic development. SOX2 knockdown in embryonic stem cells results in their differentiation. Co-expression of SOX with OCT4, MYC, and KLF4 is sufficient to reprogram somatic cells to induced pluripotent stem cells (iPSCs), which exert similar characteristics as natural pluripotent stem cells. These findings indicate that SOX2 is crucial for the self-renewal and pluripotency of embryonic stem cells. In addition, over-expression of SOX2 has been found in various types of malignant cancer. Knockdown of SOX2 results in cell cycle arrest by downregulating cyclin D1 and inhibition of tumor cell proliferation, suggesting that SOX2 is involved in activating genes associated with tumor progression.
宿主来源:
Rabbit
实验应用:
IHC, WB
靶标/特异性:
RM427 reacts to human SOX2.
同种型:
Rabbit IgG
免疫原:
A peptide corresponding to the C-terminus of human SOX2.
克隆号:
RM427
产品浓度:
N/A
保存温度:
+4°C
运输温度:
BI
产品形式:
liquid
存储溶液:
Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide.
产地:
瑞士
纯度:
Protein A purified.
促销活动
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