anti-TcdB (Clostridioides difficile exotoxin), mAb (rec.) (VIF137-E7)-单抗-深圳欣博盛生物科技有限公司

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anti-TcdB (Clostridioides difficile exotoxin), mAb (rec.) (VIF137-E7)

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：AG-27B-6335-C050

规格：50 ug

目录价：￥3492

产品详情

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产品名称:

anti-TcdB (Clostridioides difficile exotoxin), mAb (rec.) (VIF137-E7)

别名:

Clostridioides Difficile Toxin B

产品描述:

Clostridioides difficile is a spore-forming, anaerobic, and gram-positive bacterium, that opportunistically colonizes human colon and induces diseases such as diarrhea and pseudomembranous colitis. The symptoms of C. difficile infection (CDI) are mainly caused by two primary exotoxins, TcdA and TcdB, released from the bacterium. Both TcdA and TcdB belong to the family of large clostridial toxins (LCTs), which contain an N-terminal glucosyltransferase domain that modifies small GTPase proteins, a cysteine protease domain (CPD) that autocatalytically cleave the holotoxin in the cytosol, a combined domain for both delivery and receptor binding, and a C-terminal region consisting of series of combined repetitive oligopeptides (CROPs). These toxins enter host cells via receptor-mediated endocytosis and inactivate small GTPase proteins, leading to actin cytoskeleton disruption and cell death. Of the two toxins, TcdB alone is able to induce a full spectrum of diseases in both animals and humans. Although different toxin receptors have been identified, it is no valid therapeutic option to prevent receptor endocytosis. Neutralizing antibodies, directly targeting both toxins are so far the only therapeutic approaches.

宿主来源:

Protein A purified from HEK293 cell culture supernatant.

实验应用:

ELISA, FUNC, WB

靶标/特异性:

Recognizes TcdB from Clostridioides difficile.

同种型:

Human IgG1

免疫原:

Recombinant TcdB (Clostridioides difficile, strain VPI10463) containing a C-terminal His-tag.

克隆号:

VIF137-E7