anti-TIE-2 (human), mAb (tek16)-单抗-深圳欣博盛生物科技有限公司

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anti-TIE-2 (human), mAb (tek16)

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：AG-20T-0104-C100

规格：100 ug

目录价：￥5100

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

anti-TIE-2 (human), mAb (tek16)

别名:

Tyrosine Kinase with Ig and EGF Homology Domains-2; Angiopoietin-1 Receptor

产品描述:

TIE-2 acts as cell-surface receptor for ANGPT1, ANGPT2 and ANGPT4 and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. It has anti-inflammatory effects by preventing the leakage of proinflammatory plasma proteins and leukocytes from blood vessels. It is required for normal angiogenesis and heart development during embryogenesis and for post-natal hematopoiesis. After birth, it activates or inhibits angiogenesis, depending on the context. It inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1 and ultimately to the stimulation of sprouting angiogenesis.

实验应用:

ELISA, FACS, WB

靶标/特异性:

Native human TIE-2 in ELISA experiments and on the surface of different human cell types.

同种型:

Mouse IgG1

免疫原:

Recombinant human soluble extracellular domain of TIE-2.

克隆号:

tek16

保存温度:

+4°C