anti-TIGIT (human), mAb (ANCTG6/10A6) (preservative free)-单抗-深圳欣博盛生物科技有限公司

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anti-TIGIT (human), mAb (ANCTG6/10A6) (preservative free)

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：ANC-340-820

规格：100 ug

目录价：￥3542

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

anti-TIGIT (human), mAb (ANCTG6/10A6) (preservative free)

别名:

T Cell Immunoreceptor with Ig and ITIM Domains; V-set and Immunoglobulin Domain-containing Protein 9; V-set and Transmembrane Domain-containing Protein 3; Vstm3; VSIG9; WUCAM

产品描述:

TIGIT (T cell immunoreceptor with Ig and ITIM domains) is a novel member of the immunoglobulin super family (IgSF). TIGIT and CD226 bind the same ligands, the two nectin-family members poliovirus receptor (PVR) and poliovirus receptor-related 2 (CD112) and compete for each other. TIGIT inhibits while CD226 activates the signaling through PVR and CD112. TIGIT and CD226 directly interact at the cell surface and this interaction impairs CD226 homodimerization and function. TIGIT is absent on naive T cells, but is expressed on activated Tregs and memory T cells, and on NK cells and NKT cells. TIGIT negatively regulates T cell activation and blockade of TIGIT exacerbates several immune diseases. TIGIT also activates the PVR receptor on dendritic cells (DCs). Addition of TIGIT (human):Fc (human) to DCs triggers phosphorylation of PVR and elicits downstream signaling, which then inhibits T cell responses by producing IL-10. TIGIT also negatively regulates NK cell cytotoxicity and cytokine production. TIGIT is directly regulated by FoxP3 and promotes inducible Treg differentiation.

宿主来源:

Purified from concentrated hybridoma tissue culture supernatant.

实验应用:

ELISA, FACS

靶标/特异性:

Binds to receptors on a subset of human peripheral blood lymphoid cells, as well as to recombinant TIGIT in EIA.

同种型:

Mouse IgG1kappa

免疫原:

Recombinant human TIGIT.

克隆号:

ANCTG6/10A6