anti-VEGFR-2/KDR (human), mAb (3(4H3))-单抗-深圳欣博盛生物科技有限公司

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anti-VEGFR-2/KDR (human), mAb (3(4H3))

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：AG-20T-0109-C100

规格：100 ug

目录价：￥5100

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

anti-VEGFR-2/KDR (human), mAb (3(4H3))

别名:

Vascular Endothelial Growth Factor Receptor-2; KDR; FLK-1

产品描述:

Disruption of the precise balance of positive and negative molecular regulators of blood and lymphatic vessel growth can lead to myriad diseases. Although dozens of natural inhibitors of hemangiogenesis have been identified, an endogenous selective inhibitor of lymphatic vessel growth has not been previously described. A splice variant of the gene encoding vascular endothelial growth factor receptor-2 (VEGFR-2) that encodes a secreted form of the protein, designated endogenous soluble VEGFR-2 (esVEGFR-2/KDR) has been described. The endogenous soluble esKDR inhibits developmental and reparative lymphangiogenesis by blocking VEGF-C function. Tissue-specific loss of esKDR in mice induced, at birth, spontaneous lymphatic invasion of the normally alymphatic cornea and hyperplasia of skin lymphatics without affecting blood vasculature. Administration of esKDR inhibited lymphangiogenesis but not hemangiogenesis induced by corneal suture injury or transplantation, enhanced corneal allograft survival and suppressed lymphangioma cellular proliferation. Naturally occurring esKDR thus acts as a molecular uncoupler of blood and lymphatic vessels; modulation of esKDR might have therapeutic effects in treating lymphatic vascular malformations, transplantation rejection and, potentially, tumor lymphangiogenesis and lymphedema.

实验应用:

FACS, WB

靶标/特异性:

The antibody will detect native human VEGFR-2/KDR in ELISA experiments and on the surface of different human cell types.

同种型:

Mouse IgG1

免疫原:

Recombinant human soluble extracellular VEGFR-2.

克隆号:

3(4H3)

保存温度:

+4°C