anti-ZAP70 (human), Rabbit Monoclonal (RM408)-单抗-深圳欣博盛生物科技有限公司

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anti-ZAP70 (human), Rabbit Monoclonal (RM408)

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：REV-31-1294-00-R100

规格：100 ul

目录价：￥5726

产品详情

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产品名称:

anti-ZAP70 (human), Rabbit Monoclonal (RM408)

别名:

Tyrosine-protein Kinase ZAP-70; 70 kDa zeta-chain Associated Protein; Syk-related Tyrosine Kinase

产品描述:

ZAP70 is a member of the Syk tyrosine kinase family and plays a central role in lymphocyte activation and development, and is implicated in several immune disorders. Upon T cell antigen receptor (TCR) engagement, ZAP70 is phosphorylated on tyrosines 292, 315 and 319 in the interdomain B, located between the SH2 and kinase domains. Phosphorylation of both tyrosines 315 (a Vav binding site) and 319 (a Lck binding site) enhances ZAP70 function in mediating lymphocyte signaling, while tyrosine 292 terminates the transient activation of ZAP70 and attentuates lymphocyte signaling. ZAP-70 in B cells is used as a prognostic marker in identifying different forms of chronic lymphocytic leukemia (CLL). In systemic lupus erythematosus, the Zap-70 receptor pathway is missing and Syk takes its place.

宿主来源:

Rabbit

实验应用:

IHC, WB

靶标/特异性:

This antibody reacts to human ZAP70.

同种型:

Rabbit IgG

免疫原:

A peptide corresponding to residues near the N-terminus of human ZAP70.

克隆号:

RM408