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折扣/货期| 货号：82-799 | 规格：100 ul | 目录价：￥8371.35 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
LIM kinase 1(LIMK1) Rabbit Recombinant Antibody
别名:
LIMK1; LIMK; LIMK-1; LIM domain kinase 1; LIM kinase 1(LIMK1)
反应种属:
Human,Mouse,Rat
宿主来源:
Rabbit
实验应用:
WB,IHC-P, ELISA
同种型:
IgG
克隆性:
Monoclonal
纯化方式:
Affinity purification
偶联:
Unconjugated
产品浓度:
Batch dependent
保存温度:
Store at -20℃. Avoid freeze / thaw cycles.
运输温度:
Blue Ice
预期分子量:
72kDa
产品形式:
Liquid
存储溶液:
Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.
产地:
美国
生产商:
Prosci
功能与背景:
There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Accession #:
P53667
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