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折扣/货期| 货号：AG-40B-0089-3010 | 规格：3 x 10 ug | 目录价：￥7680 |
| 货号：AG-40B-0089-C010 | 规格：10 ug | 目录价：￥3840 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
APRIL (mouse) (multimeric) (rec.)
别名:
MultimericAPRIL™; ACRP30headless:APRIL; ACRP30headless:CD256; ACRP30headless:TNFSF13; ACRP30headless:A-proliferation-inducing Ligand:
产品描述:
APRIL is a cytokine that belongs to the TNF superfamily and binds to TACI and BCMA. It is implicated in the regulation of tumor cell growth, is involved in monocyte/macrophage-mediated immunological processes and functions as an important survival factor for plasmablasts and bone marrow plasma cells. MultimericAPRIL™ is a high activity construct in which two trimeric APRIL ligands are artificially linked via the collagen domain of ACRP30. This construct very effectively stimulates proliferation B cell. A basic amino acid sequence (QKQKKQ) close to the N-terminus of APRIL is required for binding to negatively charged sulfated glycosaminoglycan side chains of proteoglycans. Proteoglycans mediate binding of APRIL to tumor cells as well as primary lymphoid cells.
宿主来源:
HEK 293 cells
靶标/特异性:
Binds to human and mouse BCMA and TACI. Binds to proteoglycans.
产品浓度:
0.1mg/ml after reconstitution
保存温度:
+4°C
运输温度:
BI
预期分子量:
~34kDa (SDS-PAGE)
产品形式:
solid
存储溶液:
Lyophilized. Contains PBS + 0.5% Trehalose.
产地:
瑞士
纯度:
>95% (SDS-PAGE)
生物活性:
Stimulates B cell proliferation.
内毒素水平:
<0.02EU/µg purified protein (LAL test; Lonza).
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