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折扣/货期| 货号：34915-1 mg | 规格：1 mg | 目录价：￥817 |
| 货号：34915-10 mg | 规格：10 mg | 目录价：￥4060 |
| 货号：34915-25 mg | 规格：25 mg | 目录价：￥7102 |
| 货号：34915-5 mg | 规格：5 mg | 目录价：￥2854 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Aprocitentan
别名:
ACT-132577
产品描述:
A dual ETA and ETB receptor antagonist and an active metabolite of macitentan; inhibits ET-1- induced increases in intracellular calcium in HPASMCs (IC50 = 14 nM), ET-1-induced contractions in isolated rat aortic rings (pA2 = 6.7 for ETA), and sarafotoxin S6c-induced contractions of isolated rat tracheal rings (pKB = 5.5 for ETB); reduces ET-1-induced increases in proliferation of isolated human skin fibroblasts at 10 and 100 µM; increases plasma ET-1 concentrations in normotensive rats and decreases MAP in DOCA-salt hypertensive rats at 10-300 mg/kg
保存温度:
-20
运输温度:
-20
预期分子量:
546.1944
产品形式:
A solid
纯度:
≥98%
CAS号:
1103522-45-7
分子式:
C16H14Br2N6O4S
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