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折扣/货期| 货号：22137-1 mg | 规格：1 mg | 目录价：￥496 |
| 货号：22137-10 mg | 规格：10 mg | 目录价：￥2358 |
| 货号：22137-25 mg | 规格：25 mg | 目录价：￥5253 |
| 货号：22137-5 mg | 规格：5 mg | 目录价：￥1313 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
APS-2-79 (hydrochloride)
产品描述:
An inhibitor of KSR-dependent MAPK signaling; inhibits ATPbiotin binding to KSR2 in KSR2-MEK1 complexes (IC50 = 120 nM); stabilizes KSR2 in an inactive state; reduces interactions between B-RAF and KSR2-MEK1 complexes; inhibits KSR-stimulated phosphorylation of MEK and ERK in HEK293H cells at 5 μM; enhances the efficacy of trametinib, further reducing cell viability in K-Ras mutant HCT116 and A549 cell lines, but not B-RAF mutant SK-MEL-239 and A375 cell lines, at 1 μM
保存温度:
-20
运输温度:
-20
预期分子量:
387.44
产品形式:
A crystalline solid
纯度:
≥95%
CAS号:
2002381-31-7
分子式:
C23H21N3O3 • HCl
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