肠道菌群-深圳欣博盛生物科技有限公司

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肠道菌群

发布日期：2025-02-13

编辑：市场部

浏览次数：39

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人体内的细菌数量是人体细胞的10倍。这些微生物群广泛存在肠道上皮和粘膜细胞表面，对维持机体健康起着非常重要的作用。如果正常的共生微生物群（肠道菌群）的生态平衡发生紊乱，将严重影响人体健康，引发风湿性关节炎、炎症性肠病、多发性硬化症及糖尿病等多种疾病。除了能抵御有害病菌造成的物理及化学的伤害，肠道菌群在维持免疫功能(Th17，Treg及固有淋巴细胞)方面也发挥着重要的作用。

肠道免疫系统能区分共生菌和病原菌，对共生菌产生免疫耐受，而对病原菌及其他抗原物质产生免疫反应。Th17细胞是能产生IL-17的CD4+T淋巴细胞亚群，Th17的产生依赖于肠道共生菌的存在，并成为肠道免疫屏障的重要组成部分。它的适量存在有助于维持肠道免疫功能，而Th17的过度诱导则会导致肠道免疫功能破坏。此外，在肠道免疫系统中对共生菌耐受的CD4+CD25+Treg细胞及其产生的一致性细胞因子IL-10和TGF-β也发挥着重要作用，Th17细胞的分化发育又与Treg细胞分化发育呈抑制性关系。因此，Th17和Treg细胞是连接着肠道菌群和肠道免疫功能的关键细胞亚群。
肠道菌群.png

产品信息

产品名称	产品编号	克隆号	应用
Anti-Mouse AHR Alexa Fluor® 488	53-5925	4MEJJ	FC
Anti-Mouse AHR eFluor® 660	50-5925	4MEJJ	FC
Anti-Mouse AHR PE	12-5925	4MEJJ	FC
Anti-Human AHR eFluor® 660	50-9854	FF3399	FC
Anti-Human AHR PE	12-9854	FF3399	FC
Anti-Human AHR PerCP-eFluor® 710	46-9854	FF3399	FC
Anti-Human AHR Purified	14-9854	FF3399	FC, ICC, IHC, WB
Anti-Mouse Aiolos eFluor® 660	50-5789	8B2	FC
Anti-Mouse Aiolos PE	12-5789	8B2	FC
Anti-Mouse Aiolos Purified	14-5789	8B2	WB
Anti-Human Foxp3 PE-Cyanine7	25-4776	PCH101	FC
Anti-Human/Mouse c-Maf eFluor® 660	50-9855	sym0F1	FC
Anti-Human/Mouse c-Maf PerCP-eFluor® 710	46-9855	sym0F1	FC
Anti-Human CCL5 (RANTES) eFluor® 660	50-9905	VL1	FC
Anti-Mouse CD4 Alexa Fluor® 488	53-0041	GK1.5	FC
Anti-Mouse CD4 APC	17-0041	GK1.5	FC
Anti-Mouse CD4 APC-eFluor® 780	47-0041	GK1.5	FC
Anti-Mouse CD4 Biotin	13-0041	GK1.5	FC
Anti-Mouse CD4 Cyanine5	19-0041	GK1.5	FC
Anti-Mouse CD4 eFluor® 450	48-0041	GK1.5	FC
Anti-Mouse CD4 eFluor® 605NC	93-0041	GK1.5	FC
Anti-Mouse CD4 eFluor® 650NC	95-0041	GK1.5	FC
Anti-Mouse CD4 eFluor® 660	50-0041	GK1.5	FC
Anti-Mouse CD4 FITC	11-0041	GK1.5	FC
Anti-Mouse CD4 Functional Grade Purified	16-0041	GK1.5	FC, FA
Anti-Mouse CD4 PE	12-0041	GK1.5	FC
Anti-Mouse CD4 PE-Cyanine5	15-0041	GK1.5	FC
Anti-Mouse CD4 PE-Cyanine7	25-0041	GK1.5	FC
Anti-Mouse CD4 PerCP-eFluor® 710	46-0041	GK1.5	FC
Anti-Mouse CD4 Purified	14-0041	GK1.5	FC, IHC, IP
Anti-Human CD4 Alexa Fluor® 488	53-0048	OKT4 (OKT-4)	FC
Anti-Human CD4 APC	17-0048	OKT4 (OKT-4)	FC
Anti-Human CD4 APC-eFluor® 780	47-0048	OKT4 (OKT-4)	FC
Anti-Human CD4 Biotin	13-0048	OKT4 (OKT-4)	FC
Anti-Human CD4 eFluor® 450	48-0048	OKT4 (OKT-4)	FC
Anti-Human CD4 eFluor® 605NC	93-0048	OKT4 (OKT-4)	FC
Anti-Human CD4 eFluor® 660	50-0048	OKT4 (OKT-4)	FC
Anti-Human CD4 FITC	11-0048	OKT4 (OKT-4)	FC
Anti-Human CD4 Functional Grade Purified	16-0048	OKT4 (OKT-4)	FC, IP
Anti-Human CD4 PE	12-0048	OKT4 (OKT-4)	FC
Anti-Human CD4 PerCP-Cyanine5.5	45-0048	OKT4 (OKT-4)	FC
Anti-Human CD4 Purified	14-0048	OKT4 (OKT-4)	FC, IP
Anti-Rat CD4 APC	17-0040	OX35	FC
Anti-Rat CD4 FITC	11-0040	OX35	FC
Anti-Rat CD4 PE	12-0040	OX35	FC
Anti-Rat CD4 PerCP-eFluor® 710	46-0040	OX35	FC
Anti-Rat CD4 Purified	14-0040	OX35	FC, IHC
Anti-Mouse CD4 Biotin	13-0043	RM4-4	FC
Anti-Mouse CD4 FITC	11-0043	RM4-4	FC
Anti-Human CD25 Alexa Fluor® 488	53-0259	BC96	FC
Anti-Human CD25 APC	17-0259	BC96	FC
Anti-Human CD25 APC-eFluor® 780	47-0259	BC96	FC
Anti-Human CD25 Biotin	13-0259	BC96	FC
Anti-Human CD25 eFluor® 450	48-0259	BC96	FC
Anti-Human CD25 PE	12-0259	BC96	FC
Anti-Human CD25 PE-Cyanine5	15-0259	BC96	FC
Anti-Human CD25 PE-Cyanine7	25-0259	BC96	FC
Anti-Human CD25 PerCP-Cyanine5.5	45-0259	BC96	FC
Anti-Human CD25 Purified	14-0259	BC96	FC
Anti-Human/Non-Human Primate CD25 APC	17-0257	CD25-4E3	FC
Anti-Human/Non-Human Primate CD25 eFluor® 450	48-0257	CD25-4E3	FC
Anti-Human/Non-Human Primate CD25 PE	12-0257	CD25-4E3	FC
Anti-Human/Non-Human Primate CD25 PE-Cyanine7	25-0257	CD25-4E3	FC
Anti-Human/Non-Human Primate CD25 PE-eFluor® 610	61-0257	CD25-4E3	FC
Anti-Human/Non-Human Primate CD25 PerCP-eFluor® 710	46-0257	CD25-4E3	FC
Anti-Mouse CD25 Alexa Fluor® 488	53-0253	eBio3C7 (3C7)	FC
Anti-Mouse CD25 eFluor® 450	48-0253	eBio3C7 (3C7)	FC
Anti-Mouse CD25 Functional Grade Purified	16-0253	eBio3C7 (3C7)	FC, FA
Anti-Mouse CD25 Alexa Fluor® 488	53-0252	eBio7D4 (7D4)	FC
Anti-Mouse CD25 Biotin	13-0252	eBio7D4 (7D4)	FC
Anti-Mouse CD25 eFluor® 660	50-0252	eBio7D4 (7D4)	FC
Anti-Rat CD25 APC	17-0390	OX39	FC, IHC
Anti-Rat CD25 Biotin	13-0390	OX39	FC, IHC
Anti-Rat CD25 Functional Grade Purified	16-0390	OX39	FC, FA
Anti-Rat CD25 PE	12-0390	OX39	FC
Anti-Rat CD25 PerCP-eFluor® 710	46-0390	OX39	FC
Anti-Rat CD25 Purified	14-0390	OX39	FC, IHC
Anti-Canine CD25 eFluor® 660	50-0250	P4A10	FC
Anti-Canine CD25 FITC	11-0250	P4A10	FC
Anti-Canine CD25 PE	12-0250	P4A10	FC
Anti-Mouse CD25 Alexa Fluor® 488	53-0251	PC61.5	FC
Anti-Mouse CD25 PE-Cyanine5.5	35-0251	PC61.5	FC
Anti-Mouse CD25 Alexa Fluor® 700	56-0251	PC61.5	FC
Anti-Mouse CD25 APC	17-0251	PC61.5	FC
Anti-Mouse CD25 APC-eFluor® 780	47-0251	PC61.5	FC
Anti-Helios eFluor® 450	48-9883	22F6	FC
Anti-Mouse Dectin-1 PE	12-5859	bg1fpj	FC
Anti-Mouse ST2 (IL-33R) PerCP-eFluor® 710	46-9335	RMST2-2	FC
Anti-Human CD294 (CRTH2) eFluor® 660	50-2949	BM16	FC
Anti-Human AHR eFluor® 660	50-9854	FF3399	FC
Human IL-23 Recombinant Protein Carrier-Free	34-8239		FA
Anti-Human IL-17AF eFluor® 450	48-9179	20LJS09	FC

参考文献

1. Mathis D., Benoist C. (2011). Microbiota and autoimmune disease: the hosted self. Cell Host Microbe. 10, 297–30.

2. Hadis, U., Wahl, B., Schulz, O., Hardtke-Wolenski, M., Schippers, A., Wagner, N., Mu¨ ller, W., Sparwasser, T., Forster, R., and Pabst,

O. (2011). Intestinal tolerance requires gut homing and expansion of FoxP3+ regulatory T cells in the lamina propria. Immunity 34,

237–246.

3. Littman D.R., Pamer E.G. (2011). Role of the Commensal Microbiota in Normal and Pathogenic Host Immune Responses. Cell

Host Microbe. 10, 311-23.

4. Qin J, Li R, Raes J, Arumugam M, et. al. (2010). A human gut microbial gene catalogue established by metagenomic sequencing.

Nature. (7285):59-65.

5. Ivanov I. I., Littman D. R. (2010). Segmented filamentous bacteria take the stage. Mucosal Immunol. 3, 209–212. doi:

10.1038/mi.2010.3.

6. Wu, H.J., Ivanov, I.I., Darce, J., Hattori, K., Shima, T., Umesaki, Y., Littman, D.R., Benoist, C., and Mathis, D. (2010). Gut-residing

segmented ﬁlamentous bacteria drive autoimmune arthritis via T helper 17 cells . Immunity 32, 815–827.

7. Gaboriau-Routhiau, V., Rakotobe, S., Le´cuyer, E., Mulder, I., Lan, A., Bridonneau, C., Rochet, V., Pisi, A., De Paepe, M., Brandi, G., et

al. (2009). The key role of segmented ﬁlamentous bacteria in the coordinated maturation of gut helper T cell responses. Immunity 31,

677–689.

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