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折扣/货期| 货号：10009052-1 mg | 规格：1 mg | 目录价：￥576 |
| 货号：10009052-10 mg | 规格：10 mg | 目录价：￥2787 |
| 货号：10009052-25 mg | 规格：25 mg | 目录价：￥6271 |
| 货号：10009052-5 mg | 规格：5 mg | 目录价：￥1568 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
AS-252424
产品描述:
A PI3Kγ and ACSL4 inhibitor; inhibits PI3Kγ (IC50 = 0.03 µM); selective for PI3Kγ over PI3Kα, PI3Kβ, and PI3Kδ (IC50s = 0.94, 20, and 20 µM, respectively) but also inhibits CK2 (IC50 = 0.02 µM); prevents decreases in viability induced by RSL3 in HT-1080 cells in an ACSL4-dependent manner; nanoparticles loaded with AS-252424 reduce inflammation and ferroptosis in an ACSL4-dependent manner in the kidney and liver in mouse models of renal pedicle clamping-induced ischemia-reperfusion injury and concanavalin A-induced acute liver injury, respectively; reduces c-Kit ligand-induced LTC4 production and cPLA2, JNK, and p38 MAPK phosphorylation in bone marrow-derived mast cells at 0.5-2.5 µM; increases airway hyperresponsiveness and airway smooth muscle thickening in a mouse model of toluene diisocyanate-induced asthma at 10 mg/kg
保存温度:
-20
运输温度:
-20
预期分子量:
305.3
产品形式:
A crystalline solid
纯度:
≥95%
CAS号:
900515-16-4
分子式:
C14H8FNO4S
促销活动
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