ATG4A Antibody-多抗-深圳欣博盛生物科技有限公司

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ATG4A Antibody

品牌：NSJ Bio

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说明书

折扣/货期

货号：F54713-0.08ML	规格：0.08 ml	目录价：￥2962.25
货号：F54713-0.4ML	规格：0.4 ml	目录价：￥6343.55

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

ATG4A Antibody

产品描述:

Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). APG4A is a cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes. Preferred substrate is GABARAPL2 followed by MAP1LC3A and GABARAP.

反应种属:

Human, Mouse

宿主来源:

Rabbit

实验应用:

WB, IHC-P

同种型:

Rabbit Ig

免疫原:

A portion of amino acids 363-392 from the human protein was used as the immunogen for the ATG4A antibody.

克隆性:

Polyclonal (rabbit origin)