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折扣/货期| 货号：35420-1 mg | 规格：1 mg | 目录价：￥536 |
| 货号：35420-10 mg | 规格：10 mg | 目录价：￥3444 |
| 货号：35420-25 mg | 规格：25 mg | 目录价：￥6593 |
| 货号：35420-5 mg | 规格：5 mg | 目录价：￥1863 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
BDA-366
产品描述:
A Bcl2-BH4 domain antagonist (Ki = 3.3 nM); selective for Bcl-2 over Bcl-xL, Mcl-1, A1/Bfl-1, and Bcl-2 lacking the BH4 domain (Kis = >500, >500, >500, and 654.8 nM, respectively); binds to BH1-, BH2-, or BH3 domain-deficient Bcl-2 (Kis = 12.4, 7.6, and 23.4 nM, respectively); induces Bax activation in HT cells, which lack endogenous Bcl-2, and in HT cells overexpressing Bcl-2, indicating a context-specific Bcl-2-independent mechanism of cell death; is cytotoxic against a panel of NSCLC and SCLC cell lines (IC50s = 0.2-1.73 µM); reduces tumor growth and induces tumoral caspase-3 activation in an H460 lung cancer mouse xenograft model at 10, 20, and 30 mg/kg
保存温度:
-20
运输温度:
-20
预期分子量:
423.50488
产品形式:
A solid
纯度:
≥98%
CAS号:
1909226-00-1
分子式:
C24H29N3O4
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