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折扣/货期| 货号：20298-1 g | 规格：1 g | 目录价：￥911 |
| 货号：20298-10 g | 规格：10 g | 目录价：￥6285 |
| 货号：20298-5 g | 规格：5 g | 目录价：￥3591 |
| 货号：20298-500 mg | 规格：500 mg | 目录价：￥482 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Benserazide (hydrochloride)
别名:
Ro 4-4602
产品描述:
An AADC inhibitor (IC50 = 0.53 µM); inhibits tryptophan oxygenase and kynureninase (Kis = 41.8 and 26.4 µM, respectively, in rat liver homogenates), as well as HK2, HK1, and HK4 (IC50s = 5.5, 25.1, and 40.5 µM, respectively, for the recombinant human enzymes); is cytotoxic to SW480 cells, an effect that can be reversed by HK2 siRNA knockdown, at 50-400 µM; inhibits proliferation of SW480, LoVo, HCT116, MCF-7, and SMMC-7721 cells (IC50s = 143, 151, 181.4, 186, and 210.4 nM, respectively); reduces tumor growth in an SW480 mouse xenograft model at 300 and 600 mg/kg per day for 16 days; inhibits striatal AADC and enhances L-DOPA-induced increases in striatal dopamine levels in a mouse model of 6-OHDA-induced Parkinson's disease at 10 and 50 mg/kg
保存温度:
-20
运输温度:
-20
预期分子量:
257.24
产品形式:
A crystalline solid
纯度:
≥95%
CAS号:
14919-77-8
分子式:
C10H15N3O5 • HCl
促销活动
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