BX-795-抑制剂-深圳欣博盛生物科技有限公司

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BX-795

品牌：Cayman

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说明书

折扣/货期

货号：14932-10 mg	规格：10 mg	目录价：￥2251
货号：14932-25 mg	规格：25 mg	目录价：￥4677
货号：14932-5 mg	规格：5 mg	目录价：￥1206
货号：14932-50 mg	规格：50 mg	目录价：￥8750

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

BX-795

产品描述:

A multi-kinase inhibitor; an ATP-competitive inhibitor of PDK1 and TBK1 (IC50s = 6 and 11 nM, respectively); an inhibitor of NUAK1 (IC50 = 5 nM), and MARK1, MARK2, MARK3, and MARK4 (IC50s = 55, 53, 81, and 19 nM, respectively), as well as MLK1, MLK2, and MLK3 (IC50s = 50, 46, and 42 nM, respectively); is selective for these kinases over five additional kinases (IC50s = >1,100 nM) but does inhibit VEGFR, as well as IΚΚε and Aurora B kinase (IC50s = 41 and 31 nM, respectively); inhibits phosphorylation of Akt at Thr308 and p70S6K1 at Thr389 in PC3 prostate cancer cells (IC50 = 300 nM); inhibits secretion of IFN-β induced by LPS or poly(I:C) in RAW 264.7 macrophages at 1 µM; inhibits the proliferation of PC3 and MDA-MB-468 cancer cells (IC50s = 250 and 720 nM, respectively); inhibits the proliferation of PDK1-/- murine embryonic stem cells expressing either wild-type PDK1 or PDK1 with an L159G mutation at 5 µM

保存温度:

-20

运输温度:

-20

预期分子量:

591.5

产品形式:

A crystalline solid

纯度:

≥98%

CAS号:

702675-74-9