官网链接
折扣/货期| 货号：F53882-0.05ML | 规格：0.05 ml | 目录价：￥2962 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
COMMD1 Antibody
产品描述:
COMM domain-containing protein 1 is a proposed scaffold protein that is implicated in diverse physiological processes and whose function may be in part linked to its ability to regulate ubiquitination of specific cellular proteins. Can modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes by displacing CAND1; in vitro promotes CRL E3 activiy and dissocoiates CAND1 from CUL1 and CUL2. Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity. Involved in the regulation of membrane expression and ubiquitination of SLC12A2. Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits and by promoting their ubiquitination presumably involving NEDD4L. Promotes the localization of SCNN1D to recycling endosomes. Promotes CFTR cell surface expression through regulation of its ubiquitination. Down-regulates SOD1 activity by interfering with its homodimerization. Plays a role in copper ion homeostasis. Involved in copper-dependent ATP7A trafficking between the trans- Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes. Can bind one copper ion per monomer. May function to facilitate biliary copper excretion within hepatocytes. Binds to phosphatidylinositol 4,5- bisphosphate (PtdIns(4,5)P2). Involved in the regulation of HIF1A-mediated transcription; competes with ARNT/Hif-1-beta for binding to HIF1A resulting in decreased DNA binding and impaired transcriptional activation by HIF-1.
反应种属:
Human
宿主来源:
Rabbit
实验应用:
WB
同种型:
Rabbit Ig
免疫原:
A portion of amino acids 4-33 from the human protein was used as the immunogen for the COMMD1 antibody.
克隆性:
Polyclonal (rabbit origin)
纯化方式:
Antigen affinity
保存温度:
Aliquot the COMMD1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
产品形式:
Antigen affinity purified
存储溶液:
In 1X PBS, pH 7.4, with 0.09% sodium azide
产地:
美国
促销活动
相关产品推荐
SARS-CoV-2 Nucleocapsid Antibody
货号：RQ6297
MPO Antibody / Myeloperoxidase
货号：V9351-100UG
MPO Antibody / Myeloperoxidase
货号：V9351SAF-100UG
CEA Antibody / Carcinoembryonic Antigen
货号：V9164-100UG
CEA Antibody / Carcinoembryonic Antigen
货号：V9164SAF-100UG
AMACR / p504S Antibody (Prostate Cancer Marker)
货号：V8877-100UG
复制QQ号成功，请打开QQ后添加好友进行咨询