官网链接
折扣/货期| 货号：60-696 | 规格：400 ul | 目录价：￥8687.25 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
CRYAA Antibody
别名:
Alpha-crystallin A chain, Heat shock protein beta-4, HspB4, Alpha-crystallin A(1-172), Alpha-crystallin A(1-168), Alpha-crystallin A(1-162), CRYAA, CRYA1, HSPB4
反应种属:
Human
宿主来源:
Rabbit
实验应用:
WB
同种型:
Rabbit Ig
克隆性:
Polyclonal
纯化方式:
This antibody is purified through a protein A column, followed by peptide affinity purification.
偶联:
Unconjugated
产品浓度:
batch dependent
保存温度:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
运输温度:
Blue Ice
产品形式:
Liquid
存储溶液:
Supplied in PBS with 0.09% (W/V) sodium azide.
产地:
美国
生产商:
Prosci
功能与背景:
Crystallins are separated into two classes:
taxon-specific, or enzyme, and ubiquitous. The latter class
constitutes the major proteins of vertebrate eye lens and maintains
the transparency and refractive index of the lens. Since lens
central fiber cells lose their nuclei during development, these
crystallins are made and then retained throughout life, making them
extremely stable proteins. Mammalian lens crystallins are divided
into alpha, beta, and gamma families; beta and gamma crystallins
are also considered as a superfamily. Alpha and beta families are
further divided into acidic and basic groups. Seven protein regions
exist in crystallins: four homologous motifs, a connecting peptide,
and N- and C-terminal extensions. Alpha crystallins are composed of
two gene products: alpha-A and alpha-B, for acidic and basic,
respectively. Alpha crystallins can be induced by heat shock and
are members of the small heat shock protein (sHSP also known as the
HSP20) family. They act as molecular chaperones although they do
not renature proteins and release them in the fashion of a true
chaperone; instead they hold them in large soluble aggregates.
Post-translational modifications decrease the ability to chaperone.
These heterogeneous aggregates consist of 30-40 subunits; the
alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two
additional functions of alpha crystallins are an autokinase
activity and participation in the intracellular architecture.
Alpha-A and alpha-B gene products are differentially expressed;
alpha-A is preferentially restricted to the lens and alpha-B is
expressed widely in many tissues and organs. Defects in this gene
cause autosomal dominant congenital cataract (ADCC). [provided by
RefSeq].
Accession #:
P02489
您可能感兴趣的产品
Growth Hormone (rat) Polyclonal Antibody for IHC
货号：C03904.25 µl
Goat Anti-ImmunoglobulinG (mouse) Polyclonal Antibody
货号：C03757.10 ml
Goat Anti-ImmunoglobulinG (rat) Polyclonal Antibody
货号：C03756.10 ml
Goat Anti-ImmunoglobulinG (guinea pig) Polyclonal Antibody
货号：C03755.10 ml
Sheep Anti-ImmunoglobulinG (guinea pig) Polyclonal Antibody
货号：C03754.10 ml
Horse Anti-ImmunoglobulinG (rabbit) Polyclonal Antibody
货号：C03753.5 ml
CRF (ovine) Polyclonal Antibody
货号：C03171.500 dtn
Methionine Enkephalin Polyclonal Antibody
货号：C03170.500 dtn
复制QQ号成功，请打开QQ后添加好友进行咨询