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折扣/货期| 货号：F53829-0.05ML | 规格：0.05 ml | 目录价：￥2962 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
CTCFL Antibody
产品描述:
Testis-specific DNA binding protein responsible for insulator function, nuclear architecture and transcriptional control, which probably acts by recruiting epigenetic chromatin modifiers. Plays a key role in gene imprinting in male germline, by participating in the establishment of differential methylation at the IGF2/H19 imprinted control region (ICR). Directly binds the unmethylated H19 ICR and recruits the PRMT7 methyltransferase, leading to methylate histone H4 'Arg-3' to form H4R3sme2. This probably leads to recruit de novo DNA methyltransferases at these sites (By similarity). Seems to act as tumor suppressor. In association with DNMT1 and DNMT3B, involved in activation of BAG1 gene expression by binding to its promoter. Required for dimethylation of H3 lysine 4 (H3K4me2) of MYC and BRCA1 promoters.
反应种属:
Human
宿主来源:
Rabbit
实验应用:
WB
同种型:
Rabbit Ig
免疫原:
A portion of amino acids 617-650 from the human protein was used as the immunogen for the CTCFL antibody.
克隆性:
Polyclonal (rabbit origin)
纯化方式:
Antigen affinity
保存温度:
Aliquot the CTCFL antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
产品形式:
Antigen affinity purified
存储溶液:
In 1X PBS, pH 7.4, with 0.09% sodium azide
产地:
美国
促销活动
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