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折扣/货期| 货号：F54095-0.05ML | 规格：0.05 ml | 目录价：￥2962.25 |
| 货号：F54095-0.2ML | 规格：0.2 ml | 目录价：￥6343.55 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Cyclin D1
产品描述:
Cyclin D1 / CCND1 is the regulatory component of the Cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner. [UniProt]
反应种属:
Human, Mouse
宿主来源:
Mouse
实验应用:
WB
同种型:
Mouse IgG1, kappa
免疫原:
Recombinant human Cyclin D1 was used as the immunogen for the Cyclin D1 antibody.
克隆性:
Monoclonal (mouse origin)
克隆号:
1849CT557.93.5
纯化方式:
Protein G purified
保存温度:
Aliquot the Cyclin D1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
产品形式:
Purified
存储溶液:
In 1X PBS, pH 7.4, with 0.09% sodium azide
产地:
美国
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