| 货号:45580-10 mg | 规格:10 mg | 目录价:¥3752 |
| 货号:45580-5 mg | 规格:5 mg | 目录价:¥1997 |
产品详情
* 以下信息仅供参考,详情请以原厂网站为准
产品名称:
Dabuzalgron (hydrochloride)
别名:
Ro 115-1240
产品描述:
An α1A-AR partial agonist; selectively binds to α1A-AR over α1B- and α1D-ARs in CHO-K1 cells expressing the recombinant human receptors (Kis = 0.041, 1.6, and 6.5 µM, respectively); selectively induces inositol phosphate accumulation in α1A-AR-expressing CHO-K1 cells over those expressing α1B- or α1D-ARs (EC50s = 0.204, >100, and >100 µM, respectively); induces urethral tension in rabbit bladder neck preparations (EC50 = 0.363 µM); increases intraurethral pressure and diastolic arterial pressure in anesthetized micropigs (ED50s = 41 and 36 µg/kg, i.v., respectively); increases urethral tension but does not affect diastolic arterial pressure or heart rate in conscious micropigs at 300 µg/kg); decreases cardiac fibrosis and prevents decreases in heart rate and fractional shortening in a mouse model of doxorubicin-induced cardiotoxicity at 10 µg/kg, p.o.
保存温度:
-20
运输温度:
-20
预期分子量:
317.788
产品形式:
A solid
纯度:
≥95%
CAS号:
219311-43-0
分子式:
C12H16ClN3O3S • HCl
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