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折扣/货期| 货号：23557-1 mg | 规格：1 mg | 目录价：￥482.4 |
| 货号：23557-10 mg | 规格：10 mg | 目录价：￥3162.4 |
| 货号：23557-5 mg | 规格：5 mg | 目录价：￥1809 |
| 货号：23557-50 mg | 规格：50 mg | 目录价：￥13440.2 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Delanzomib
别名:
CEP-18770
产品描述:
An inhibitor of chymotrypsin-like proteasome activity (IC50 = 3.8 nM); pre-treatment in vitro with a concentration of 20 nM inhibits IκBα degradation, NF-κB activation, and the expression of NF-κB-regulated genes, including IκBα, XIAP, TNF-α, IL-1β, ICAM1, and VEGF; induces apoptosis in multiple myeloma cell lines and inhibits proliferation in a panel of human hematologic and solid tumor cell lines (IC50s = 5.6-34.2 nM); reduces tumor weight in an RPMI 8226 human multiple myeloma mouse xenograft model when administered intravenously at doses ranging from 1.5-4 mg/kg twice daily and leads to complete tumor regression at a chronic oral dose of 13 mg/kg; efficacious in a mouse model of fata lupus nephritis
保存温度:
-20
运输温度:
-20
预期分子量:
413.3
产品形式:
A crystalline solid
有效期:
1460
纯度:
≥95%
CAS号:
847499-27-8
分子式:
C21H28BN3O5
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