官网链接
折扣/货期| 货号：15220-10 mg | 规格：10 mg | 目录价：￥2854 |
| 货号：15220-25 mg | 规格：25 mg | 目录价：￥4623 |
| 货号：15220-5 mg | 规格：5 mg | 目录价：￥1796 |
| 货号：15220-50 mg | 规格：50 mg | 目录价：￥7450 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Dovitinib
别名:
CHIR258|TKI-258
产品描述:
A multi-kinase inhibitor; inhibits FLT3, CSF1R, c-Kit, FGFR1, FGFR3, VEGFR1, -2, and -3, PDFGRα, and PDGFRβ (IC50s = 1, 36, 2, 8, 9, 10, 13, 8, 27, and 210 nM, respectively); inhibits proliferation of human multiple myeloma cell lines expressing mutant, but not wild-type, FGFR3 (IC50s = 90-550 and >2,500 nM, respectively); decreases FGF-induced ERK1/2 phosphorylation and induces apoptosis in patient-derived multiple myeloma cells at 500 nM; inhibits bFGF-induced angiogenesis in a Matrigel™ plug assay in mice at 3-300 mg/kg for 8 days; reduces tumor growth in KM12L4A, DU145, and MV4-11 mouse xenograft models (ED50s = 17, 23, and 3 mg/kg per day, respectively)
保存温度:
-20
运输温度:
-20
预期分子量:
392.4
产品形式:
A crystalline solid
纯度:
≥98%
CAS号:
405169-16-6
分子式:
C21H21FN6O
促销活动
精品推荐
复制QQ号成功，请打开QQ后添加好友进行咨询