| 货号:29476-1 mg | 规格:1 mg | 目录价:¥536 |
| 货号:29476-10 mg | 规格:10 mg | 目录价:¥2774 |
| 货号:29476-5 mg | 规格:5 mg | 目录价:¥1554 |
产品详情
* 以下信息仅供参考,详情请以原厂网站为准
产品名称:
DS-437
产品描述:
A dual inhibitor of PRMT5 and PRMT7 (IC50s = 5.9 and 6 μM, respectively); selective for PRMT5 and PRMT7 over a panel of 29 additional protein, DNA, and RNA methyltransferases at 50 μM, but also inhibits DNMT3A and DNMT3B (IC50s = 52 and 62 μM, respectively); inhibits symmetrical arginine dimethylation of FOXP3 in HEK293T cells at 2.5 and 10 μM; inhibits the ability of Tregs to suppress Teff proliferation in vitro in human and murine Treg suppression assays; reduces tumor growth in a CT26Her2 murine colon cancer model when administered at 10 mg/kg five times per week in combination with the anti-p185erbB2/neu antibody 4D5
保存温度:
-20
运输温度:
-20
预期分子量:
397.4539
产品形式:
A solid
纯度:
≥98%
CAS号:
1674364-87-4
分子式:
C15H23N7O4S
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