官网链接
折扣/货期| 货号：37311-1 mg | 规格：1 mg | 目录价：￥389 |
| 货号：37311-10 mg | 规格：10 mg | 目录价：￥2640 |
| 货号：37311-25 mg | 规格：25 mg | 目录价：￥5655 |
| 货号：37311-5 mg | 规格：5 mg | 目录价：￥1420 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
DT2216
产品描述:
A PROTAC that drives Bcl-xL degradation; selectively induces degradation of Bcl-xL in MOLT-4 cells (DC50 = 63 nM; Dmax = 90.8%) over washed isolated human platelets (Dmax = 26% at 3 µM); selectively binds to Bcl-xL and Bcl-2 over Bcl-W (Kis = 12.82, 1.82, and 300.9 nM, respectively), but does not induce degradation of Bcl-2 or Bcl-W in RS4;11 cells at 1 µM; cytotoxic to MOLT-4 cells but not washed isolated human platelets (EC50s = 0.052 and >3 µM, respectively); induces cleavage of caspase-3 in MOLT-4 cells at 100 and 300 nM; reduces tumor volume and weight in a MOLT-4 mouse xenograft model at 15 mg/kg; acts synergistically with ABT-199 in an NCI H146 mouse xenograft model and docetaxel in an MDA-MB-231 mouse xenograft model
保存温度:
-20
运输温度:
-20
预期分子量:
1542.359449
产品形式:
A solid
纯度:
≥98%
CAS号:
2365172-42-3
分子式:
C77H96ClF3N10O10S4
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