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折扣/货期| 货号：45472-1 mg | 规格：1 mg | 目录价：￥388.6 |
| 货号：45472-10 mg | 规格：10 mg | 目录价：￥2720.2 |
| 货号：45472-25 mg | 规格：25 mg | 目录价：￥5346.6 |
| 货号：45472-5 mg | 规格：5 mg | 目录价：￥1648.2 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Eclitasertib
别名:
DNL758|SAR443122
产品描述:
A RIPK1 inhibitor (IC50 = 0.0375); inhibits necroptosis induced by TNF-α, a Smac mimetic, and Z-VAD-FMK in HT-29 cells (EC50 = 0.0154 µM, respectively); inhibits necroptosis induced by IFN-γ, TNF-α, Z-VAD, and an Smac mimetic and reduces cytokine levels induced by the same combination in primary human keratinocytes at 4 nM; reduces epidermal thickness, reverses disruptions in epidermal architecture, and reduces IL-1RA release in 3D keratinocyte skin equivalents generated from primary human keratinocytes and stimulated with mixed lesional T cell supernatants prepared from LP and CLE patient-derived skin biopsies; reverses TNF-α- and Z-VAD-induced hypothermia in a mouse model of systemic inflammatory response syndrome
保存温度:
-20
运输温度:
-20
预期分子量:
378.392
产品形式:
A solid
有效期:
1460
纯度:
≥98%
CAS号:
2125450-76-0
分子式:
C19H18N6O3
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